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교수진

신찬석 교수

Chanseok Shin

전공생화학
주소200동 7121호
연락처02-880-4643
이메일cshin@snu.ac.kr
학력사항

B.S. Seoul National University, Korea, 1991

M.S. Seoul National University, Korea, 1995

Ph.D. Columbia University, USA, 2004

경력

Postdoctoral research associate, Columbia University, USA, 2004

Postdoctoral research fellow, Whitehead Institute for Biomedical Research, USA, 2004-2009

수상

John S. Newberry Prize for the most promising student of the year in the field of zoology, Department of Biological Sciences, Columbia University, New York, NY. 2003

 

Postdoctoral fellowship from Damon Runyon Cancer Research Foundation, 2005-2008

연구 관심분야

MicroRNA와 long non-coding RNA에 의한 유전자 발현 조절 메커니즘 연구

 

핵산-단백질 상호작용 연구

 

RNAi 이용한 생화학 농약 개발 기반 연구

대표 논문

Shin, C., Nam, J.-W., Farh, K.K.-H., Chiang, H.R., Shkumatava, A., Bartel, D.P. (2010). Expanding the microRNA targeting code: functional sites with centered pairing. Mol. Cell 38, 789-802

Shin, C. (2008). Cleavage of the star strand facilitates assembly of some microRNAs into Ago2-containing silencing complexes in mammals. Mol. Cells 26, 308-313.

Baek, D*., Villen, D*., Shin, C*., Camargo, F.D., Gygi, S.P., and Bartel, D.P. (2008). The impact of microRNAs on protein output. Nature 455, 64-71.
* These authors contributed equally to this work.

Matranga, C., Tomari, Y., Shin, C., Bartel, D.P., and Zamore P.D. (2005). Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell 123, 607-620.

Shin, C., Kleiman, F.E., and Manley, J.L. (2005). Multiple properties of the splicing repressor SRp38 distinguish it from typical SR proteins. Mol. Cell. Biol. 25, 8334-8343.

Shin, C., and Manley, J.L. (2004). Cell signalling and the control of pre-mRNA splicing.
Nature Rev. Mol. Cell Biol. 5, 727-738.

Shin, C., Feng, Y., and Manley, J.L. (2004). Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock. Nature 427, 553-558.

Shin, C., and Manley, J.L. (2002). The SR protein SRp38 represses splicing in M phase cells. Cell 111, 407-417.

Shin C., Choi, J.N., Song, S.I., Song, J.T., Ahn, J.H., Lee, J.S., and Choi, Y.D. (1996). Loop B domain of hairpin ribozyme is physically separable from loop A domain. Nucleic Acids Res. 24, 2685-2689.